1842 - On March 30, Dr. Crawford W. Long administered the first anesthetic using ether in Jefferson, Georgia, a small community 60 miles northeast of Atlanta. However, this event was not publicized.
1844 - On December 11, Dr. Horace Wells, a dentist, inhaled nitrous oxide while a fellow dentist painlessly extracted one of Dr. Well's teeth. However, Dr. Wells' attempt to produce anesthesia using nitrous oxide at Massachusetts General Hospital in 1845 failed and the use of nitrous oxide for medical purposes fell into disrepute.
1846 - On Friday, October 16, Dr. William Thomas Green Morton, a dentist from Harford, Connecticut, and Dr. Well's partner, administered ether to Mr. Gilbert Abbott for the removal of a tumor by the well-known surgeon Dr. John C. Warren at Massachusetts General Hospital . An account of this event appeared in the Boston Daily Journal the next day.
1847 - Dr. James Y. Simpson, a highly respected obstetrician in England, administered ether to a mother during labor. However, it wasn't until Dr. John Snow, another English physician, administered chloroform to Queen Victoria during the birth of Prince Leopold in 1853 that obstetrical analgesia gained public acceptance. Dr. Snow was the first physician to devote his medical practice to the administration of anesthetics, making him the first anesthesiologist.